• Age ≥ 18 and ≤ 80 years.

• CLL/SLL is diagnosed by histopathology and/or flow cytometry according to the 2016 World Health Organization (WHO) classification criteria for lymphohematopoietic neoplasms or meeting the criteria of 2018 International Workshop on Chronic Lymphocytic Leukemia (iwCLL 2018):

• Having an indication for treatment that meets the criteria for iwCLL 2018

• Subjects must have measurable lesion according to the Lugano 2014 Assessment Criteria.

• Patients with an Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of ≤ 2 and a life expectancy of ≥ 6 months.

• Adequate hematologic function

• Patients with basically normal coagulation function

• Patients with adequate hepatic, renal, pulmonary and cardiac functions

• Subjects are able to communicate with the investigator well and to complete the study as specified in the study.

⁃ Before the trial, the subjects shall understand the nature, significance, possible benefits, inconveniences and potential risks, as well as the study procedures of the trial in detail and voluntarily sign the written Informed Consent Form (ICF).